Abstract: Due to overrun of carbon monoxide in the coal seam, this is seriously interfere with the work of prediction to coal seam spontaneous combustion, based on the theory of gas-solid coupling theory, it has been conducted from the microscopic structure and macroscopic factors two aspects to research permeability rule comprehensive coupling of carbon monoxide in coal seam. Research findings, coal seam of exceeding carbon monoxide concentration have low metamorphic degree, and have rich side chain and the oxygen containing functional groups, contains a lot of closed holes and semi-closed air hole, the carbon monoxide in coal seam permeability is far less than the gas permeability at the same time, create the conditions for carbon monoxide accumulation in the coal seam; the relationship between carbon monoxide permeability and gas pressure present in the form of index decreases, and this is generally in accordance with gas permeability rule in coal seam; in addition, temperature had a greater influence on the carbon monoxide seepage in the coal seam, with the increase of temperature the carbon monoxide permeability decrease but there are obvious accumulation phenomenon, this is similar to the permeability rule of gas and provide certain theoretical basis to research on the carbon monoxide transfinite phenomenon in coal seam.