Abstract: To explore the coupling relationship between the mining goaf coal spontaneous combustion and the gas explosion, according to the different characteristics of the three stages of spontaneous combustion and taking a constant volume reactor as a model, the numerical simulation software CHEMKIN was used to simulate the diversification of key reaction basis of before and after gas explosion under different stages and different conditions of spontaneous combustion. Calculation results of comparative analysis showed that: the gas explosion was inhibited in the slow oxidation stage; the gas explosion was promoted in the accelerating oxidation stage; the gas explosion was slightly promoted in the violent oxidation stage.