Abstract: Abstract: In order to study the feasibility of preventing and controlling coal spontaneous combustion by priming inhibitor solution ,taking the 3 upper coal seam in Nantun mine as an example ,selecting four kids of inhibitors through the inhibition experiments and carrying out pre-injection experiments of inhibitor solution by using a self-made device.The pre-injection effect of several inhibitor solution was compared by testing the moisture increment of the coal samples .The coal spontaneous combustion characteristics comprehensive test system was used to test the shortest spontaneous ignition period of the coal samples before and after the pre-injection of the inhibitor solution, and the coal quality before and after the pre-injection of the inhibitor solution was analyzed. The results show that the pre-injection effect of the inhibitor solution is affected by the type of inhibitor and the concentration of the inhibitor solution. The experimental shortest spontaneous ignition period of coal can be effectively prolonged by pre-injection of the inhibitor solution. The four inhibitors extended the experimental shortest spontaneous combustion period of coal by 12.6%, 10.7%, 9.3% and 8.1% respectively. The effect of the pre-injection of the inhibitor solution on coal quality was acceptable.