Abstract: In order to ensure the effective control and utilization of the natural wind pressure in deep mines, the field measurement method was adopted. Taking the mining area of Tengdongshengjian Coal Mine as an example, the variation law of natural wind pressure and the phenomenon of air leakage in the goaf due to its change were carried out the study. The research shows that the natural variation of natural wind pressure in deep horizontal mines is like a sinusoidal curve, and the change of natural wind pressure leads to the regular change of the trend of the inlet and outlet winds in the goaf. When the natural wind pressure is reduced, the gap between the inner and outer pressures of the closed area of the goaf is increased, the air leakage trend is obvious, and the air volume is increased. If the trend of air leakage into the air in the confined area is the incoming air, the air intake trend in the airtight area is weakened or even reversed. When the natural wind pressure increases, the gap between the inner and outer pressures of the closed area of the goaf is reduced, the wind entering trend is obvious, and the air intake is increased. If the air leakage trend in the closed area of the goaf is air leakage, the air leakage trend in the airtight area is weakened, and even becomes the air inlet.