Abstract: In this paper, ultrafiltration, nanofiltration, reverse osmosis and electrodialysis were studied, and the characteristics of different membrane separation techniques were analyzed. The application points of membrane separation technology in water desalination, reduction, material concentration and salt separation of high-salt mine water were summarized, and the advantages and disadvantages of different membrane combination technologies were compared. The application examples and operating costs of membrane separation technology in several typical high-salt mine water treatment projects were introduced. The importance and development prospects of membrane separation technology in such engineering applications were pointed out, and providing experience and reference for the design of subsequent similar projects.