Abstract: In order to solve the difficulties including gangue disposal, disaster management and ecological protection that affect efficient coal mining, the five-in-one safe and green mining method featuring isolated grouting-filling for overburden rock and waste disposal, washout prevention, vibration damping, water preservation and sedimentation reduction was proposed for millions of tons of coal gangues. The research proposes a step-type self-flowing slurry production and transportation method, which solves many problems such as large-scale processing, system stability and energy saving, land occupation and long-distance transportation. The method has been tested in the Hulusu Coal Mine of China National Coal Group Corp, and the demonstration project has realized the production capacity of 700,000 t/a in the first phase, and it will reach 1.5 million t/a after the the second phase. The cost of disposing tons of gangues is RMB 50 per ton, saving about RMB17.3 million of the cost of gangue and water disposal. The amount of surface subsidence of the slurry filling area has been reduced by 52.9-53.2% and the average water influx in the working face has been reduced by 17.7-29.1%, The frequency of rock burst energy decreased by 774 times, a decrease of 30.5%. The project has achieved great results in terms of economy, safety and environmental protection, realized safe and green mining, and played a positive demonstration role for the coal mines in Inner Mongolia and Shaanxi.