Abstract: Based on the south slope of Antaibao open-pit mine as the research object, consider the strength of rock slope is decreased, and the formation and occurrence of the rock mass are changed when the collapse column and other geological structures occur in open-pit mine end wall inside. The stability of the south slope is simulated and analyzed under the effect of collapse column with GeoStudio, and the unstable region of slope is delineated, put forward the control measures of the inner-dumping with burying slope combined with the actual situation. The results show that the control measure is more effective, and the discharge capacity of open pit mine was increased, shorten the distance of dumping, and it is important practical significance to the safety production of open pit mine.