Abstract: The vertical three-way pipe are common pipe fittings in the filling pipeline system, and the flow resistance affects the operating energy consumption of the entire pipeline system. In this paper, the experimental parameters were obtained by using the whole tailings to prepare filling slurry. The Fluent numerical simulation software was used to simulate the two flow modes of the filled slurry in the three-way pipe. According to the velocity and pressure distribution of the filling slurry, the local and path resistance loss of the pipeline is analyzed. Combined with numerical calculation, the local resistance coefficient of the two types of pipes is obtained and the reasons for the changes are analyzed. It has certain guiding significance for the filling pipeline design of mines.