Abstract: With the increase of resources exploration in the western area of China,the contradiction of coordinated exploitation amongmulti-energy minerals wereappearedgradually in Ordos Basin, where enrichedoil, gas, coal,uranium,etc.The most prominently is between in-situ uranium leaching and coal mining. Take Tarangaole coal mine for example, the lithologic character of coal seam roof from341 boreholes inthe shaft area and outflow testdata wereanalyzed. It shows thatthemaximum drawdownof coal mining influenceto groundwater is about 224.33m, which might damage the hydrogeological conditions of uranium mining. According to the mining conditions, four kinds of coal mining methodswere analyzed, such as filling mining, room-pillar mining,strippillar mining and fully-mechanized caving method. The result shows that water-control mining on fully-mechanized caving methodwerefeasible and available.In order to optimize the mining plan for minimize the influenceto groundwater, themajor mining conditions were analyzed which includingdestruct height of overlying strata,thickness of aquifuge,characteristic of having aquifers, requirements of production, etc.The calculation result shows thatthe water inflow of the optimum mining face is 229m3/h whenaquifers were destroyedpartially, and the maximum drawdown of groundwaterwere 45.86mafter20 years, whichcan significantly reduce the influenceto uranium mining conditions.