Abstract: In order to find out the exact location and water rich situation of F32 fault in front of the main shaft driving in a mine in Huainan, in view of the diversity of knowledge and multi solutions of results in a single geophysical method, a multi parameter comprehensive geophysical method combining reflection seismic method and transient electromagnetic method is proposed to detect F32 fault in advance. In addition, with the help of numerical simulation and physical model test, the advance exploration of geological conditions in front of shaft driving is systematically studied. The research results show that the comprehensive advance detection of various geophysical methods can improve the accuracy of the interpretation of the geological conditions ahead of the excavation, in which the reflected seismic wave method can locate the location of the geological interface, and the transient electromagnetic method can judge the water rich characteristics of the structure based on the analysis of electrical characteristics, and can assist in determining the location of the geological interface. The field application shows that the fault F32 is located in the section of -786.8-792.8m, and the overall water content of the rock stratum is not strong; the detection results provide effective technical parameters for the mine design and safe construction of the shaft, and also provide reference for similar projects.