Abstract: Abstract: In the engineering background of guizhou coal mine in sand-layered transportation lane 141713, about the mine transportation lane deep high stress soft rock supporting problem hard, roadway destruction features through the field investigation and laboratory with multi-function powder X-ray diffraction analysis of surrounding rock composition, the article analyses the failure mechanism of roadway, it is concluded that low intensity of surrounding rock and clay minerals content of the supporting way, unreasonable, mining effect, high stress, and the main causes of water seepage is the deformation of roadway surrounding rock. According to the characteristics and mechanism of roadway failure, the combined support scheme of "anchor cable + steel mesh + grouting + u-beam steel shed" was proposed, which was verified by theoretical analysis, numerical simulation analysis and field measurement. After numerical simulation support, the maximum subsidence of roadway roof and the maximum floor heave of roadway decreased from 160mm and 60mm to 45mm and 40mm respectively.The maximum movement of the two sides of the roadway decreased from 60mm to 14mm; The maximum principal stress increased from 24MPa to 28MPa. The field monitoring results show that the maximum convergence rate of roadway section after support is 9.87%, the deformation of roadway surrounding rock is under control, and the support effect is obvious Key words: High stress soft rock; Grouting; The roadway supporting; Numerical simulation; Monitoring