Abstract: In view of the problems of gas prevention and control, production cost and connection during stoping in the multi-entry arrangement of fully mechanized caving face in Baode County coal mine, the optimization scheme of roadway layout and the ventilation of working face and gas drainage in Goaf based on this condition are put forward, through the comparison and analysis of technology and economy, the layout of the roadway and the gas control method during the working face stoping are determined and perfected, the field test proves that the optimization scheme is reasonable and feasible, and its safety, economic and social benefits are obvious before the optimization. The optimization scheme of roadway layout has been popularized and applied in Baode County coal mine. Based on the good effect of gas prevention and control after optimization of roadway layout in fully mechanized caving face in Baode County coal mine, it can provide a useful reference for roadway layout and gas prevention and control in fully mechanized caving face under similar conditions.