Abstract: In order to explore the influencing factors of rheological parameters of gangue paste like slurry during pipeline transportation, taking the gangue paste like filling slurry of Gonggeyingzi mine as the engineering background, the rheological parameters of gangue paste like filling slurry under different concentration and gangue particle size were measured by CRT rheometer. The stress of gangue particles in paste like slurry is analyzed by using hydrodynamics and particle transportation hydraulics. The slurry flow state and particle trajectory under different flow velocity, gangue particle size and slurry concentration were simulated and verified by FLUENT software. The results show that the particle size and concentration of gangue paste slurry affect the plastic viscosity and initial shear stress of the slurry, and then affect the critical flow rate of pipeline transportation. Specifically, in the process of pipe transportation, gangue particles with particle sizes of 15mm and 20mm are more likely to sink than those of 5mm and 10mm. When slurry concentration reaches 76%, the increase of initial shear stress of slurry increases sharply. As slurry concentration increases, gangue particles are less likely to settle in the process of pipe transportation. This study has certain reference significance for setting parameters of gangue paste like filling slurry and engineering practice.