Abstract: In view of the problems of large coagulant dosage and poor coagulation and sedimentation effect of high suspended matter mine water treatment in a mine in Jizhong Energy Fengfeng Group, multiple coagulation and sedimentation processes were used to study the effects of coagulant type, flocculant type, coagulation times, coagulant（flocculant）dosage method and dosage, reaction speed and other factors on the removal of suspended matter in mine water. The results showed that the best coagulant was PAC, the best flocculant was CPAM, the coagulation times were twice, the best dosage method and dosage were 70mg/L PAC and 0.3mg/L PAM for once, 20mg/L PAC and 0.3mg/L PAM for the twice, the dosage of PAC was reduced by 25% compared with the conventional coagulation, the best speed is 210 r/min for fast stirring and 60 r/min for slow stirring. Engineering applications show that: the use of dual coagulation and sedimentation process to treat high suspended mine water, the removal of suspended solids and turbidity effect is significant, the effluent water quality is stable and up to standard, saving water resources and drug cost, with good economic and environmental benefits.