Abstract: Coal mine gas is one of the causes of major disasters. Low extraction concentration and poor effect are common pain points in engineering practice. Aiming at the technical problems of low average concentration and short duration of gas extraction in coal mine and the field requirements obtained from engineering practice, interface modification methods such as mechanical modification method and organic activation modification method were selected, and bentonite as the base material was used to improve water retention, stability and thixotropy, and liquid phase sealing materials for gas drilling were developed. The idea of "liquid sealing gas" is adopted to realize full - cycle thixotropic sealing of nascent cracks. The application results of Renlou Coal Mine show that the new material has good plugging effect, and the average extraction concentration is 41.66%, which is 15.27% higher than that of the traditional material. Concentration attenuation coefficient decreased by 48%; Slurry lifting coefficient increased by 22%; Can realize waste hole utilization. The new type of sealing material will have good application value in the field of gas extraction and disaster control in coal mine.