Abstract: In order effectively avoid the occurrence of goaf water hazard, the method of geophysical exploration combined with drilling in the goaf area is explored, and the comprehensive treatment measures are adopted. Based on seismic wave anomalies in the gob, the location and scope of the goaf region are delineated by three-dimensional seismic. There is a great difference between the resistivity of goaf area and surrounding rock. The low-resistivity anomaly area is determined by transient electromagnetic method, and the goaf area is further explored. The goaf area delimited by three-dimensional seismic and transient electromagnetic method was verified through the construction of ground drilling, and the goaf area was explored by controlled source charging method using the borehole to reveal the goaf area. The potential difference contour line of different frequencies was used to verify and correct the scope and location of the goaf area. After the exploration of the goaf area of the closed mine by geophysical exploration and drilling, the water in the goaf area was drainaged by underground long distance directional drilling and ground drilling respectively, and the water in the goaf area was pumped out by the ground large-diameter drilling combined with high-flow submersible pump and booster pump in pipeline. The research results show that the location and scope of the goaf area can be accurately delineated by geophysical exploration combined with drilling, and the water in the goaf area can be drainaged and pumped by underground drilling and ground drilling respectively, which can effectively solve the threat of goaf water hazard to the surrounding coal mine.