Aiming at the problem of dynamic disaster caused by the fracture of thick and hard roof in the mining process, taking the 11-3107 working face of Menkeqing Coal Mine as the engineering background, the layout method of fracturing horizontal drilling in thick and hard roof area is deeply explored by means of theoretical analysis, numerical simulation and field practice. Firstly, through the multi-dimensional analysis of roof lithology analysis, key layer discrimination, energy transfer research and microseismic monitoring, it is determined that there are key layers I, II and III in the overlying strata of 3107 working face, and their breaking has high energy transfer to coal body. It is comprehensively determined that the middle and low positions of 15-30 m and the middle and high positions of 45-60 m are fracturing horizons and need dynamic adjustment. Secondly, the numerical simulation is used to analyze the water injection leakage in different mining failure ranges, and the horizontal borehole layout parameters are determined, and the pre-splitting effect of roof blasting is evaluated. Based on the above research, the regional fracturing scheme of 3107 working face is put forward, which provides a solid technical support for the subsequent safe and efficient mining of 3107 working face in Menkeqing Coal Mine.