Aiming at difficulties for actual seismic design of shaft tower structure. The theoretical analysis method was used to explore the seismic response of the shaft tower under the interaction mechanism of piles, soil, well bore, and shaft tower. Based on the Winkler foundation beam theory, Penzien centralized quality theory and elastic half-space theory of foundation vibration, the theoretical analysis simplified model of piles-soil-well bore-shaft tower system is constructed. Combined with the structural dynamics theory, the dynamic motion equation in the time domain under earthquake action is established. Based on the MATLAB software platform, the seismic response analysis and solution system of the shaft tower is developed. Finally, the piles-soil-well bore-shaft tower system of a large mine is taken as the research object. The influence of site category, foundation and foundation form and seismic wave on the seismic response of the shaft tower is compared. The results show that, the enhancement coefficients of the tower acceleration of shaft tower are concentrated within 1.72~2.12, 1.23~1.71 and 1.02~1.51 respectively under Ⅱ、Ⅲ and Ⅳ site categories. The softer the site, the smaller the tower acceleration enhancement coefficients of the shaft tower. In the design of pile-raft foundation shaft tower, it is necessary to consider the interaction of piles-soil-well bore-shaft tower, which is crucial to ensure the stability and safety of the shaft tower structure．