Abstract: During the natural oxidation of coal, different concentrations of component gases will be generated at different stages, Based on this, this paper designs and implements a multi-sensor measurement system. The infrared CO2 sensor, electrochemical carbon monoxide sensor, primary cell oxygen sensor, infrared gas sensor and digital temperature and humidity sensor were selected as measuring components. Designed measurement circuits for each sensor according to industry standards to ensure the reliability of sensor data. The system adopts a modular design concept to facilitate later upgrade and expansion. The test results show that the system meets the requirements of coal-related industry standards. The system has certain practical value for the quantitative study of spontaneous combustion of coal and the prediction of coal spontaneous combustion.