Abstract: Abstract: Combined with the current technical status that a large number of low-concentration gas and ventilation air methane in the coal mining area cannot be effectively utilized，the author introduces in detail the design of safety mixing and regulation using low concentration gas storage oxidation. Explaining the principle and technical requirements separately，putting forward specific technical indicators，and introducing the application of system engineering about safety mixing and regulation using low concentration gas storage oxidation. Design and operation of field applications showed that the system is safe，reliable and stable. It can meet the gas demand of gas oxidation comprehensive utilization project.