Abstract: Abstract: At present, "time and space" advanced regional exploration and control technology are still have some problems in exploring the design of treatment, the mechanism of grouting transformation and the evaluation of treatment effect. Through the analysis of water inrush types and engineering examples of deep mining floor in Hanxing mining area, the application of this technology in the prevention and control of high pressure water hazard in deep seam floor of Hanxing mining area is studied, and the countermeasures are put forward in view of the problems existing in the application of this technology. Water inrush types of deep seam floor in Hanxing mining area can be divided into three categories: 1 Water inrush types of Ordovician karst water+fault and subsidence column; 2 Water inrush types of Ordovician karst water→Daqing karst water + fault and subsidence column; 3 Water inrush types of goaf water + fault and subsidence column. Type 1 Grouting treatment horizon should select the karst development site at the top of Ordovician lime; Type 2 Should Choose Daqing Limestone; Type 3 should choose the aquifer of Daqing limestone and the location of vertical structure development. Problems in Regional Advanced Exploration and Governance Technology : It is pointed out that geological and hydrogeological conditions should be fully combined in the design of exploration and control engineering; In grouting renovation, theoretical research on grout diffusion mechanism and field test should be carried out to further determine grouting technology and horizontal hole layout distance; The harnessing effect should be re-evaluated through Combining Quantization by Iterative Exponential Method by using water inrush coefficient, water inrush from aquifer, mine water inrush, structural discovery rate and initial Ordovician karst water pressure index and other indicators.