Abstract: The equivalent permeability of the 3D fractured porous media is predicted based on fracture geometrical parameters of 3D model, the matrix permeability and permeability of 2D cut plane. 3D models of fractured porous media with different fracture characteristics were established, and the equivalent permeability of 2D/3D model were calculated. The results show that the equivalent permeability of the 2D cut plane is much smaller than the 3D equivalent permeability. The effects of fracture geometric parameters and matrix permeability coefficients on the equivalent permeability of the 3D model were quantified. Through regression analysis, a 3D equivalent permeability prediction expression based on 3D rock mass fracture length, density, matrix permeability and 2D equivalent permeability is obtained. This study provides the possibility to use the surface matrix-fracture characteristics to predict the permeability of 3D fractured porous media.