Abstract: Aiming at the complex hydrogeological conditions and the current situation of the underground normal drainage system of Lilou Coal Mine, in order to increase the mine's ability to resist flood disasters, design proposes a new mine disaster-resistant drainage system in the underground depot. Through theoretical calculations and program comparison, adopted the 'inclined lane connection + horizontal installation + floor layout' system arrangement, determined the selection of water pump and drain pipe, drew the pump characteristic curve. The disaster-resistant drainage system of Lilou Coal Mine is reasonably arranged, the equipment runs well after the project is implemented, The actual use effect meets the design requirements. The mine's ability to resist sudden flood disasters has been greatly improved, which has a good reference for the design and application of coal mine disaster-resistant drainage pump rooms.