Abstract: Abstract: CFB boiler power generation with coal slime based on pipeline transportation is the best way to utilize coal slime. However, the pipeline transportation of coal slime has large resistance and no-far transportation distance, which is difficult to meet the needs of the future coal industry towards the integration of coal and electricity. It is urgent to reduce the transportation resistance of coal slurry pipelines and increase the transportation distance. Co-firing coal slime has an impact on CFB boiler performance, and the problems of incomplete and unsystematic understanding of which by engineers are prominent. In view of the above problems, this paper puts forward that the characteristics of slip layer are the key factors affecting the transportation resistance of coal slurry pipelines. A sliding drag reduction effect testing device was designed, the relationship between transport resistance and sliding layer thickness was revealed, and the recommended value of sliding layer thickness for engineering application was put forward. The influence of coal slime mixing on CFB boiler operation performance is summarized from eight aspects, such as bed temperature, bed pressure and boiler efficiency, which provided a theoretical reference for the technology application of Co-firing coal slime for CFB boilers in power plants.