Abstract: In order to reveal the law of influence of air volume on wind resistance in fully mechanized mining face, the 215211 fully mechanized mining face in Shenmu Shiyaodian Coal Mine, Shaanxi Province, was taken as the research object, and wind resistances of working face under different air volume conditions were measured on site. On this basis, the complex spatial geometric model of 215211 fully mechanized mining face was constructed by using CFD flow field simulation method. Combining REG k-εturbulence model, the wind flow field calculation model of fully mechanized mining face was established. The structure characteristics of the flow field was simulated and analyzed. It was proved that the ventilation resistance loss of fully mechanized mining face was local resistance loss. On this basis, the wind resistance values of mining face under different air volume conditions were solved. The characteristic curve and function formula of air volume-resistance in fully mechanized mining face was fitted by numerical analysis method. The relationship between wind resistance and air volume was quadratic parabola. The relative error between the calculated results of function formula and the measured results of wind resistance was less than 5%.The research showed that the CFD flow field simulation method could be used to study the air flow law of complex spatial structure such as fully mechanized mining face. The wind flow-resistance characteristic curve of the mining face obtained in this paper provided vital wind resistance parameters for accurate calculation of mine ventilation network.