Abstract: In order to study the influence of mining sequence of upper and lower coal seams on the pressure behavior of interlayer coal strata in compound residual mining area, taking the compound residual mining area formed after mining the upper and lower coal seams of Xishan Coal Power Baijiazhuang Coal Mine by using the cutter pillar method and the long wall caving method respectively as the research object. The method of combining site survey, theoretical analysis and numerical simulation were used to research the influence of mining sequence on upper and lower coal seams on the stress distribution, movement and deformation, failure characteristics of abandoned coal and its surrounding rock in the middle part of the coal seams. Research results show that: 1) Compared with the mining sequence of “downward and upward”, when the mining sequence was "upward and downward", the degree of stress concentration in the middle coal seam and the surrounding rock are lower after the mined of the upper and lower coal seams, and the stress effect caused by double mining is smaller; 2) When the mining sequence is "upward and downward", the displacement deformation of coal and rock strata are smaller than that is "downward and upward" mining sequence; 3) When the mining sequence is "upward and downward", the rock mass below the cutter pillar isn’t damaged by plastic collapse and which means that the overall stability of the coal seam in the middle of the area is better. This paper provide support for the safe mining of abandoned coal in the middle of the compound residual mining area.