Abstract: Open-pit coal mine belongs to semi-open space, which will produce a lot of dust in coal mining. The transportation link is line dust source, which lasts for a long time and contributes a lot to dust production. In order to study the dust migration law of truck transportation in open-pit mine, taking Anjialing open-pit mine as the research object, this paper analyzes the variation law of dust concentration in transportation link of Anjialing open-pit mine by means of theoretical analysis, numerical simulation and field monitoring, and puts forward dust removal suggestions. The results show that the dust concentration in the transportation process does not exceed the relevant national standards in most of the time, and the dust pollution area caused by truck driving is concentrated in the contact position between tires and the ground. Dust accumulation is easy to occur at the gap between the front and rear wheels of the truck. The highest concentration in this area is 4.9mg/m3. The highest concentration of dust is 1.62mg/m3 at the height of 3m at the tail of the truck, and the maximum diffusion concentration is 1.28ug/m3 at the height of 7m, 20m away from the tail of the truck. The research results can put forward targeted dust control measures for dust accumulation locations and diffusion areas in transportation links to achieve effective dust control.