Abstract: In the process of coal mining, CO generation during coal mining is unavoidable. A small amount of CO will threaten the safety of workers. In order to protect the physical and mental health of workers and improve the environment under the mine. By using plasma technology, an experimental platform was established to study the effectiveness and influencing factors of plasma elimination of CO. The experimental results showed that the plasma had the best effect on CO elimination when the output voltage was 50kV and the electrode material was beryllium copper alloy. The higher the wind speed, the worse the elimination effect; With the increase of oxygen concentration and humidity, the amount of CO elimination shows an upward trend, with the best CO elimination effect at wind speed of 0.6m/s, oxygen concentration of 20.5%, and humidity of 30% RH.