The article summarized the water quality characteristics of domestic wastewater from coal mine industrial sites in northern Shaanxi through the analysis of the incoming water quality of domestic wastewater from several large-scale coal mines． Aiming at the composition and biochemical characteristics of coal mine sewage，we designed“mechanical grid + sedimentation tank + A/O tank + MBR”sewage treatment process routes of coal mine in northern Shaanxi Province． The effluent quality of domestic wastewater treatment has been monitored for a long period of time to analyze the effectiveness of domestic wastewater treatment and adjust the operating parameters according to the effluent conditions． The results of engineering practice showed that the removal effect of this process on the pollutants BOD5 and NH3-N in the coal mine domestic wastewater reacheed more than 90% and 80%，and the produced water met the water quality standard of mine reuse water． This study helped ensure the stable operation of domestic wastewater treatment during coal mine production，reduce the cost of domestic wastewater treatment，and reuse to meet the standard． The study aimed to provide relevant cases for coal mine domestic wastewater treatment and reuse technology，and provide experience and reference for the design of similar projects．