Aiming at the problem of the large deformation of surrounding rock of deep high stress roadway, the main transportation roadway in the tenth mining area of Shuiyu Coal Industry Co., Ltd. was selected as the research object, combined with field investigation, theoretical analysis and field test, The failure characteristics of surrounding rock and supporting structure of deep high stress roadway, the internal structure and strength characteristics of roof and two sides were analyzed, and the main influencing factors of large deformation of surrounding rock of roadway were studied. Based on the research results, a combined structure including grouting, bolting, concreting and supporting with confined concrete support and grouting anchor cable as the core was proposed, the industrial test was carried out on site, which effectively guaranteed the stability of surrounding rock of deep high stress roadway, which has a certain reference value for the control of surrounding rock of roadways with similar conditions.