Due to the advantages of no pollution, environmental protection and low cost, pure water hydraulic system is becoming the focus of research in the field of hydraulics to replace the traditional emulsion system. In this paper, the accuracy and reliability of the pressure loss simulation model of each unit of the pipeline in the AMEsim software are used to establish a single-inlet single-circuit, double-inlet double-circuit and three-inlet three-circuit simulation model of the liquid supply pipeline layout based on the ZY29000 / 45 / 100 D support hydraulic system. The pressure loss performance in different pipeline layouts under emulsion and pure water media is analyzed. The results show that under the experimental model conditions, the pressure loss along the pure water medium is 20 % -30 % lower than that of the emulsion medium pipeline. With the increase of the number of liquid supply pipeline branches, the pressure loss advantage of the pure water medium is more significant. However, it is necessary to comprehensively consider the stability of the working face of the balance lifting system and the pipeline cost.