Abstract: Based on the need of coal mine safety production and automatic set control system, the paper studies the domestic coal mine drainage monitoring system, and puts forward the Ifix configuration software as the platform, adopting Siemens ' S7-300PLC series module. The mine drainage centralized control system based on iFix is designed and implemented, and successfully applied to Renlou mine drainage system. The hardware and software design of the system are introduced. Through simulation and field test, the results show that the system can realize automatic data acquisition, fault monitoring and alarm, rational start-up and centralized control of pumps. A new energy saving method of water pump is proposed, which realizes better energy saving effect.