Abstract: At present, the design of heat transfer effect of heat pipe heat exchanger for mine return air has great deviation from the actual application.Threlkeld method based on enthalpy difference is used to analyze the heat transfer coefficient and fin efficiency under the mine return air in wet conditions. Furthermore, the heat transfer model of single heat pipe heat pipe is established, and the heat transfer analysis of heat pipe heat exchanger is carried out by the method of pipe by pipe .The results show: In practical application, the total heat transfer coefficient of the heat exchanger has little change, so it can be regarded as fixed heat transfer coefficient. There is a big difference between the mine return air and the surface temperature of heat pipe fins on the return air-side of heat exchanger, so the surface temperature of the return air-side of heat exchanger should be greater than 0℃.