Abstract: In view of the large variation of coal seam thickness in fully mechanized caving face and the waste of coal resources caused by excessive section coal pillar, the 6107 working face of Hongshuliang Coal Mine is taken as the engineering background. Based on the thickness change of coal seam, the 6107 working face is divided into three regions. Combined with the methods of theoretical analysis, numerical simulation and field test, the widths of the optimal section coal pillars in the western region, the central region and the northern region of the 6107 working face are 14 m, 19 m and 11 m, respectively. The auxiliary roadway needs to be arranged straightly, and the width of section coal pillar in three regions is comprehensively studied. Finally, the overall section coal pillar width of 6107 working face is determined to be 17 m. The sub-regional support technology controls the stability of roadway surrounding rock. The research results have been successfully applied to engineering practice, providing a useful reference for roadway layout under similar conditions.