Abstract: In order to solve the problems such as the influence of secondary mining on the return air chute of 110 working face in Mataihao coal mine and the difficulty of the original support in maintaining the stability of the roadway, the methods of field investigation, engineering geological analysis and borehole peeping are adopted. It can be seen that the roof and floor of the coal seam are mostly soft rock, which is easy to soften and deform in case of water, the stress environment is complex, and the original support cannot be effectively coupled with the surrounding rock are the main reasons for the deformation of the surrounding rock of the roadway. Numerical simulation is used to study the influence of mining on roadway stability in 108 and 110 working faces, and an optimization scheme of high-strength and high prestress yielding anchor mesh support is proposed, which is verified by numerical simulation and underground industrial test. The results show that the optimized support system can effectively couple with the surrounding rock, give full play to the active support effect of high prestressed bolts, enhance the mechanical properties of the surrounding rock, greatly improve the roadway support efficiency and significantly reduce the surface displacement. The anchor mesh cable coupling support system of 110 return air chute in Mataihao coal mine is established, which provides technical support and safety guarantee for safe and efficient production of the roadway.