Abstract: During the close distance coal seam mining, the surrounding rock deformation and failure of the lower coal seam roadway is affected by many factors. In this paper, based on the 2-2 upper and 2-2 middle coal mining in Gaojialiang Coal Mine, the stress distribution of coal seam floor in different width sections of 2-2 upper coal seam is obtained according to the load transfer formula of coal pillar floor. There are four main influencing factors of coal pillar width in upper coal seam section, coal pillar width in lower coal seam section, layer spacing and coal pillar spacing. Then, the numerical simulation scheme is designed by orthogonal experiment. The area of the surrounding plastic zone of the coal roadway is the index. The influence of the above factors on the roadway damage of the 2-2 coal seam in Gaojialiang Coal Mine is studied. The test results show that the significance order of the surrounding rock failure of the 2-2 middle coal seam roadway in Gaojialiang Coal Mine is: layer spacing > coal pillar spacing > coal pillar width of the lower coal seam section > coal pillar width of the upper coal seam section. This study has certain guiding significance for the development and stability control of the 2-2 middle coal seam roadway in Gaojialiang Coal Mine.