Abstract: At present, there are cross transportation problems in many open-pit mine transportation systems in China, such as Pingshuo East open-pit mine, Pingshuo Anjialing Mine, Xiwan open-pit mine and Hequ open-pit mine. In order to avoid the potential safety hazard caused by plane crossing of transportation system, most open-pit mines adopt independent stripping transportation system and raw coal transportation system. However, the independent transportation system directly leads to the sharp increase of stripping transportation distance and high transportation cost, which seriously affects the economic benefits of open-pit mines. Years of practice in traffic management system has proved that proper setting of interchange facilities is the most effective solution to improve the overall transport efficiency. This paper introduces the application of steel box girder bridge in the overpass project of Shengli West No.2 open-pit mine. Through the study of bridge layout, structure analysis and benefit calculation, it is proved that the application of steel box girder bridge in the overpass project of Shengli West No.2 open-pit mine is technically feasible and the economic benefit is obvious. It can be used as a reference for solving similar cross transport problems in open-pit mines.