Abstract: As a sort of widely used material in mining construction, the systematic research for diffusion of clay-cement slurry in fractures is necessary, to optimize the long-time condition that grouting parameters design and practical engineering depend on empirical formulas. Based on the fundamental equations of fluid, the radical diffusion equations of generalized Bingham liquid are theoretically derived in a plane fracture. For the condition of long-time grouting in the bore at a time, the motion equations of radical diffusion of clay-cement slurry in the horizontal fracture are discussed, to compare the differences of grouting pressure with and without the consideration of temporal variation character of rheology parameters, and demonstrate the relationship among the fracture aperture, grouting flowrate, rheology parameters and the grouting pressure over time-dependent behavior. The results show that the grouting pressure of slurry is greatly influenced by temporal variation character of slurry, for a long period of grouting time in one time. For the case of constant grouting flowrate, the relationship between fracture aperture and grouting pressure is nonlinear. The wider fracture aperture, the lower grouting pressure would reach. Besides the width of fracture aperture have more influence on grouting pressure, comparing with the temporal variation character of slurry. Otherwise, the grouting flowrate and then time-dependent behavior takes dominant influence on grouting pressure, with the growth of diffusion distance, under the condition of different grouting flowrates. Also, there exist a nonlinearly positive relationship between the temporal variation character and grouting pressure. The influence effect would be more remarkable with growth of diffusion distance.