To improve the main well net lifting capacity, TDS intelligent coal separation system has been more and more widely applied to the underground instances. This article discusses the operating rules of the system, analyzes its corridor and cavern group layout form and cross-section, and elaborates on its plane layout and vertical layout. It summarizes two main layout methods that have a significant impact on the height of TDS intelligent coal separation main cavern rooms, based on their different layout methods, and explores the selection of supporting measures for TDS intelligent coal separation main cavern rooms in large cross-section. On this basis, based on the actual production system of the Three Rivers Mining Mine, the underground TDS intelligent coal separation system corridor and cavern group layout design example is presented, providing a reference for similar mine transformation and design projects.