Abstract: In order to determine the optimal sectional coal pillar width in the mining area, on the basis of establishing the comprehensive decision-making index system for the width of the coal pillar in the section, the basic principles of the analysis at level method (AHP), the entropy method, the weighted gray correlation analysis method (GRA) and the weighted TOPSIS method are used to construct a comprehensive decision-making system for the width of the sectional coal pillar, and the comprehensive decision-making scheme of multiple sections of the coal pillar width is optimized. In the process of optimization, the weight vectors of each decision-making index are obtained by combining AHP and entropy weight methods, and combined with the advantages of grey correlation analysis method (GRA) and the ranking method (TOPSIS) method of approximation ideal solution, a comprehensive decision-making model is established to quantitatively analyze the proposed selection scheme, and the comprehensive decision-making ranking of the sectional coal pillar width design scheme is carried out. Taking the preferred coal pillar width scheme in the Fengjiata coal mine section as an example, the relative fit of the seven proposed schemes is 52.88%, 58.99%, 36.39%, 31.96%, 42.13%, 42.15% and 52.81%, respectively, and the optimal of the second scheme is determined, that is, the coal pillar width is 11m. After on-site practice verification, it shows that the comprehensive decision-making system has considerable feasibility and effectiveness, and provides a new calculation method for determining the width of the coal pillar in the section.