Abstract: In order to study the rock burst risk caused by the disturbance of multiple coal pillars in full-mechanized caving mining, the stress disturbance calculation models of lateral section coal pillar, overlying remnant coal pillar and the coal pillar of stopping line were built respectively by using the limit equilibrium theory and stress disturbance angle, which were based on the actual distribution of coal pillars of 9203 working face in Danshuigou mine. The disturbance dangerous areas of the different coal pillars were obtained. And the control and early warning technologies of rock burst under the disturbance of multi-pillars were provided, which mainly included the pressure relief technology of boreholes and the monitoring technology of the coal stresses, micro-seismic events and drilling cuttings inspection. The results show that the disturbance dangerous areas of lateral section coal pillar, overlying remnant coal pillar, the coal pillar of overlying and lateral stopping line are respectively the areas from the roadway’s sides to the 7.2m deeper, from the lateral section coal pillar to the 39.8m deeper of working face end along the dip direction of working face, from the overlying stopping line to the 47m deeper of gob, and the areas of the lateral section coal pillar and working face end form the start points of the lateral stopping line to the stopping line of mining working face. After the control and early warning technologies applied, there were no the early warning of stresses and micro-seismic events in the field, and it had a good application effect.