Abstract: Aiming at the problems of serious dust pollution and poor dust removal effect on the fully-mechanized mining face with large mining height, this study took Daliuta Coal mine mining layer working area as an example, and optimized the spray parameters by using numerical simulation. By combing and comparing the existing spray dust removal technologies, a comprehensive dust removal technology combining support dust collection, spray inside and outside coal machine and dust source tracking spray was proposed. The performance of the optimized spray dust removal system was verified by field experiments, and the field application and effect test were carried out. The results show that HH9.5 nozzles are preferred when the wind speed is 1.0~1.5m/s, and HH9.5 and SB203 nozzles are used when the dust production is large. With the increase of pressure, the spray area and high concentration spray area showed an upward trend, and the economic benefit was the best when the pressure was 6MPa. The dust removal rates of total dust and exhaled dust can reach 92.69~96.24%, 83.61~90.07%, and the total dust mass concentration in the working face space can be as low as 20mg/m3 and 10mg/m3 respectively. In summary, the spray comprehensive dust removal technology can effectively reduce the dust concentration of the working face, improve the safety level of coal mine production, and provide a useful reference for the dust control work of the fully-mechanized mining face with large mining height.