Abstract: Aiming at the technical problems such as large deformation and serious support failure of deep soft rock roadway in a mine of Pingmei, the deformation characteristics and instability failure mechanism of high stress soft rock roadway are analyzed by means of field investigation, theoretical analysis, numerical simulation and industrial test. The synergistic integrated control mechanism of roadway surrounding rock is put forward, and the synergistic integrated control scheme of ' deep and shallow anchoring grouting + deep anchor cable reinforcement + pressure relief groove pressure relief ' is designed. Through theoretical calculation, it is veri-fied that the ultimate bearing capacity of the cooperative surrounding rock bearing body after support is greater than its bearing capacity; FLAC3D simulation shows that the design scheme can make the internal and external surrounding rock structure cooper-ate with each other, fully release the plastic deformation energy around the roadway, and evenly distribute the surrounding rock load. After the roadway is re-supported, the influence range of surrounding rock stress is transferred to the 10 m deep area of the roadway, and the surrounding rock-support achieves a bearing structure with uniform load. The monitoring data of the mine show that after one year of roadway repair, the maximum displacement is less than 4% of the width of the roadway, the maximum sub-sidence is less than 5% of the height of the roadway, and the deformation of the roadway tends to be stable.