Coal spontaneous combustion is one of the main disasters in mine, which will cause many problems such as energy waste. Coal fired power plants are the main source of CO2 concentrated emission. The content of inert gas in flue gas of power plant is over 80%, and the content of oxygen is below 10%. Injecting flue gas of power plant into underground goaf can not only seal CO2 and other gases, but also prevent spontaneous combustion of coal left in goaf. Firstly, the feasibility of injecting flue gas of power plant into goaf to prevent spontaneous combustion of residual coal is summarized from the aspects of low oxygen concentration and coal adsorption. Secondly, the advantages and technical route of sealing goaf by flue gas of power plant are expounded. Finally, the development of fire prevention and extinguishing technology by injecting flue gas of power plant into goaf is prospected. It is considered that it is feasible and promising to seal goaf with flue gas of power plant, but gas monitoring and leakage prevention still need to be improved. Future research focuses on the long-distance transportation and storage of flue gas. This technology is expected to help China achieve the goal of carbon peak in 2030 and carbon neutrality in 2060 early.