Aiming at the optimization design of mine area prevention and control of rock burst in cooperative mining of double coal seams, based on the specific engineering conditions of Taohutu Coal mine in Nalin He Mining area, The analysis shows that there are some problems in the current mining design scheme of the mine, such as unreasonable selection of protective layer, wrong opening or stop-mining line, some areas are located outside the protection range, loss of triangular coal, adverse recovery of protective coal pillar in the late main roadway and too concentrated mining in the early stage of the mine. In view of the above problems, from the perspective of rock burst prevention and control, this paper puts forward the priority mining of 2-2 coal seam as the protection layer of 3-1 coal, makes adjustments to the layout of roadway and working face, and gives the optimization design scheme of cooperative mining of single wing and double wing coal seam, which can effectively avoid the problems existing in the current mining design scheme. Based on mine geology and mining technical conditions, combined with relevant standards and specifications, the reasonable fault distance and lag distance of cooperative mining of two coal seams in mine are calculated: the reasonable dip fault distance is 30 m, the strike fault distance is 47 m, and the working face of 3-1 coal seam should lag behind the working face of 2-2 coal seam 1200 m.