In order to further study the overburden movement law, mine pressure manifestation law, and deformation and failure mechanism of self-formed roadway during the whole process of mining without coal pillar, a three-dimensional physical model test system of self-formed roadway was developed. The test system is com-posed of reaction main frame system, hydraulic servo loading system, coordinated control and monitoring system, etc. Through the test system and the self-developed unit plate, unit strip and unit block structure, the fast excava-tion and mining of the roadway are realized. Through the pre-installed internal displacement, stress, strain moni-toring equipment, can be real-time monitoring of the whole working face of the whole process of cutting and un-loading pressure into the lane. Based on the engineering background of Anju Mine, the first coal mine over a kilometer deep mine in China, a large-scale physical model test of 110 mining method was carried out, which re-vealed the mining pressure development rule of 110 mining method, and clarified the deformation control mech-anism of surrounding rock of self-formed roadway. The model test results are basically consistent with the field monitoring data, which verifies the rationality and effectiveness of the development and application of the model test system.