In the Liupan area of Changping Mine, the surrounding rock in the main roadway suffered severe deformation (fragmentation) under the influence of superimposed stress. The simple use of anchor cables for support was ineffective. Therefore, this paper adopted the technology of grouting reinforcement and anchor cable support to control the deformation of the surrounding rock. The UDEC software was used to simulate the diffusion law of the slurry and the reinforcement effect, and FLAC3D was employed to further analyze the manifestation of mine pressure in the main roadway after the grouting and anchoring. The UDEC simulation results showed that as the water-cement ratio and the injection pressure increased, the diffusion radius of the slurry also increased. The water-cement ratio of the slurry should not be less than 0.7:1, and the injection pressure should be greater than 4 MPa. Grouting reinforcement enhanced the anchoring force of the fractured surrounding rock, significantly reduced the range of plastic zone in the roadway surrounding rock and the displacement of the roadway. The FLAC simulation showed that after conducting grouting in the main roadway and then implementing anchor cable support, the deformation of the roadway was significantly reduced. After grouting reinforcement, the southwest auxiliary transportation roadway, which was most affected by the superimposed stress, had a top and bottom plate displacement of 69.73 mm, and the side wall displacement was 67.46 mm. The grouting anchoring support technology had achieved the stability of the roadway, providing certain reference value for the stability of the surrounding rock of similar working conditions' roadways.