Abstract: Based on the experiment theory and heat and mass transfer theory, large enthalpy difference cooling and dehumidification experiment system is designed, which will study different spray pressure, gas-water ratio, cooling effect and thermodynamic performance of large enthalpy difference device that can realize spray water face to face and from one side in spray water temperature. The results show that large enthalpy difference cooling device is strong in adaptability, which can meet the cooling demand of mining area with different thermal damage. The heat exchange coefficient and the heat exchange efficiency are calculated. The results show that the heat exchange efficiency and heat exchange coefficient of the counter spraying method are 0.952 and 0.998 respectively, while the heat exchange efficiency and heat exchange coefficient of the downstream spraying method are 0.936 and 0.978 respectively. Consequently, the cooling and dehumidification effect of counter spraying method is slightly better than that of downstream spraying method. And the empirical formula of heat exchange efficiency coefficient and heat contact coefficient of large enthalpy difference cooling device is obtained by fitting the experimental data, which can more accurately guide the design of cooling project of mining area in thermal damage mine and large enthalpy difference cooling device.