The east side of the Anjialing Open-pit Coal Mine is facing the problem of approaching the mining boundary. In order to master the propagation law of blasting vibration and its influence on surrounding buildings, TC-4850 blasting vibration meter is used for monitoring. The linear regression analysis method is used to calculate the values of K and α, and the formula of attenuation law of particle peak vibration velocity is obtained. The reliability of the formula is verified by comparing the predicted value with the measured value. By introducing the safety guarantee coefficient and combining with the allowable value of vibration velocity of general civil buildings in Blasting Safety Regulations, the safety allowable distance is calculated, and the relationship between the safety allowable distance in three directions and the maximum single stage charge is obtained as Rx=28.484Q1/3, Ry=27.513Q1/3, Rz=27.791Q1/3, respectively, which provides a reference for the blasting parameter design of Anjialing coal mine.